|
KMID : 0624620090420120794
|
|
BMB Reports
2009 Volume.42 No. 12 p.794 ~ p.799
|
|
|
Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production
|
|
Lee Byung-Ryong
Kim So-Young
Kim Dae-Won
An Jae-Jin
Song Ha-Yong
Han Kyu-Hyung
Lee Kil-Soo
Park Jin-Seu
Choi Soo-Young
Eum Won-Sik
Yoo Ki-Yeon
Kang Tae-Cheon
Won Moo-Ho
Lee Kwang-Jae
KIm Kyung-Hee
Joo Jin-Ho
Ham Hun-Ju
Hur Jang-Hyun
Cho Sung-Woo
|
|
|
Abstract
|
|
|
|
The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu β-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. The polysaccharide significantly inhibited (P ＜ 0.01) LPS-induced iNOS and COX-2 expression levels in the cells. Furthermore, topical application of polysaccharide resulted in markedly inhibited (P ＜ 0.01) TPA-induced ear edema in mice. These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.
|
|
|
KEYWORD
|
|
|
Agrocybe chaxingu, β-glucan, Cyclooxygenase-2 (COX-2), Lipopolysaccaride (LPS), Nitric oxide (NO)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|